- A Case of Graves' Disease Associated with Guillain-Barre Syndrome.
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Ji Hyun Lee, Ki Sung Ahn, Sang Chae Lee, Jung Dong Bae, Yong Bum Park, Soo Mi Keum, Jin Hyung Park, Jong Won Choi, Ji Yong Choi, Sung Kook Jang, Ho Sang Son
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J Korean Endocr Soc. 1997;12(4):614-620. Published online January 1, 2001
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- Graves disease, an autoimmune endocrine disorder, which causes defects in cellular and humoral immunity, is associated with insulin-dependent diabetes mellitus, Addisons disease, pemicious anemia, and rheumatoid arthritis. Graves disease is associated with various neuro-muscular disorders, such as myopathy, exophalmous oculopathy, periodic paralysis, myastenia gravis and rarely Guillain-Barre syndrome. Guillain-Barre syndrome is considered as an autoimmune disease which can occur concurrently with other autoimmune disorders. This syndrome is characterized by segmental demyelination and axonal degeneration in electrophysiology due to autoantibody to nervous systems via cellular and humoral autoimmunity. In Graves disease, the exact mechanism of the associated Guillain-Barre syndrome is not well understood but it is considered that the autoimmunity is the leading cause of development of both diseases. A 37 year-old man had suffered from thyrotoxic symptoms and progressive symmetrical muscular paralysis. In nerve conduction velocity studies, the result shows peripheral neuropathy; axonopathy; myelinopathy; motor nerve and sensory nerve derangement; right first sacral nerve neuropathy; and decreased CMAP amplitude. The patient was treated with propylthiouracil and high dose intravenous immunoglobulin (400mg/kg/day for Sdays). He responded to the therapy well and became euthyroid state with improvement of muscle weakness. We report a case of Graves' disease associated with Guillain-Barre syndrome with brief review of literature which shows a possible relationship between both diseases.
- Adrenal Myelolipoma Confirmed by Fine Aspiration Biopsy.
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Young Sik Jung, Jun Ho Whang, Jeon Ho Yang, Hyeon Soo Shin, Ih Geun Kim, Ki Sung Ahn, Sung Gug Chang, Sang Chae Lee, Jung Dong Bae, Ho Sang Shon, Mi Ok Park, Jae Bok Park, Yeong Hwan Lee
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J Korean Endocr Soc. 1997;12(1):105-110. Published online January 1, 2001
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- Adrenal myelolipomas are rare, benign tumors cornposed of mature fat and bone marrow elements. Most are small, asymptomatic tumors found incidentally at postmortem examination, Fine needle aspiration biopsy can be used to confirm the diagnosis and avoid an unnecessary operation. We report a case of adrenal myelolipoma confirmed by fine needle aspiration biopsy. A 77-year-old woman with complaining of upper abdominal pain for 2 days was found to have an adrenal mass. She took dexamethasone frequently for 3 years due to multiple arthralgia. Ultrasono-graphy showed a 6cm-sized, suprarenal mass and a stone in the gall bladder with thickened wall. Computed tomography and magnetic resonance imaging scan also presented a suprarenal mass. Endocrinologic results were within normal limits. Adrenal myelolipoma was confirmed by computed tomography-guided fine needle aspiration biopsy without surgery.
- A Case of Focal Type Nesidioblastosis in Adult Treated with Distal Pancreatectomy.
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Dae Gyu Seo, Wang Sik Shin, Gil Sung Han, Jae Gun Jung, Ho Sang Shon, Ki Sung Ahn, Hoon Kyu Oh, Jae bok Park, Young Jin Kim
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J Korean Endocr Soc. 1994;10(2):136-141. Published online November 6, 2019
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- Nesidioblastosis, the process of differentiation of pancreatic islets from ductular epithelium, is a frequent cause of hyperinsulinemic hypoglycemia in neonates and infants, but rare in adults. A 38-year-old man had suffered from intermittent hypoglycemic symtoms for 10 years. He had inappropriately elevated plasma immunoreactive insulin level and I/G ratio during a prolonged fast. There was no evidence of tumor on the abdominal CT scan and operation although celiac angiography showed a round mass like lesion in the distal pancreatic area.His hypoglycemic symptoms were improved by distal pancreatectomy.Pathologic finding in the resected pancreas was that of focal type nesidioblastosis I.e, increased size and number of islets with scattered numerous small islets around ductules in focal lesion. Distal pancreatectomy as an initial operation may be effective in the treatment of focal type nesidioblastosis.
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